New research suggests that people who come off popular weight-loss injections like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who stop conventional lifestyle regimens.
Research printed in a leading health publication shows that while obese individuals often shed a large proportion of their total mass while on the medication, the weight returns at an estimated rate of 0.8 kg per month after stopping.
"People buying such treatments need to be informed of the potential of rapid rebound weight gain when the medication is stopped," warns lead investigator Dr. Susan Jebb.
Such speed of recovery means a reversion to starting mass within about a year and a half.
Comparing Therapies
The study, which examined 37 of trials involving over 9,000 of patients, compared the outcomes of GLP-1 agonists with conventional dieting.
Scientists emphasize that people who shed pounds through lifestyle changes alone generally see a more gradual creep back—around 100 grams monthly—after stopping.
The Reason for the Quick Rebound
Experts believe the mechanism of the jabs explains the accelerated regain.
GLP-1 drugs copy a body's own chemical called GLP-1, which moderates feelings of fullness.
"Long-term administration of GLP-1 concentrations far above than normal may cause the system to produce less of its own natural hormone, and may also diminish sensitivity to its effects," explained Dr. Adam Collins, a nutrition researcher.
"Stopping of this GLP-1 'fix' results in appetite is no longer kept in check, making binge eating far more likely."
A Chronic Disease?
The NHS advise the injections for individuals with weight-linked health risks, alongside prescribed lifestyle changes.
Professionals contend that, considering the high risk of relapse, the therapy might need to be long-term.
This perspective is reinforced by drug manufacturers, who state that the findings "underscore the long-term nature of excess weight," comparing it to managing conditions like diabetes.
Patient Accounts
Individuals who have come off the jabs describe a intense resurgence of hunger.
"I experienced a trigger that goes on and I was suddenly extremely hungry," recalled an individual.
This difficulty is exacerbated if users have not developed lasting lifestyle or habit changes during therapy.
Widespread Interest
Survey data suggest that a significant number of adults in the UK have tried these injections in the last 12 months, with desire continuing to grow.
- Use is greater among women than males.
- The 40s and 50s age group shows the highest usage rates.
- Many access the medications through private prescriptions rather than the NHS.
In conclusion, experts caution that while GLP-1 drugs are effective tools for shedding pounds, they are not a standalone fix and maintained weight loss likely depends on ongoing behavioural management.
